A Post-Transcriptional Feedback Mechanism for Noise Suppression and Fate Stabilization

Optimal feedback strength for noise suppression in autoregulatory gene networks.

Autoregulatory feedback loops, where the protein expressed from a gene inhibits or activates its own expression are common gene network motifs within cells. In these networks, stochastic fluctuations in protein levels are attributed to two factors: intrinsic noise (i.e., the randomness associated with mRNA/protein expression and degradation) and extrinsic noise (i.e., the noise caused by fluctu...

Microphone Array Post-Filtering For Non-Stationary Noise Suppression

Suppression and enhancement of transcriptional noise by DNA looping.

DNA looping has been observed to enhance and suppress transcriptional noise but it is uncertain which of these two opposite effects is to be expected for given conditions. Here, we derive analytical expressions for the main quantifiers of transcriptional noise in terms of the molecular parameters and elucidate the role of DNA looping. Our results rationalize paradoxical experimental observation...

Feedback Stabilization over Signal-to-Noise Ratio Constrained Channels∗

There has recently been significant interest in feedback stabilization problems over communication channels, including several with bit rate limited feedback. Motivated by considering one source of such bit rate limits, we study the problem of stabilization over a signal-to-noise ratio (SNR) constrained channel. We discuss both continuous and discrete time cases, and show that for either state ...

Coupling transcriptional and post-transcriptional miRNA regulation in the control of cell fate

miRNAs function as a critical regulatory layer in development, differentiation, and the maintenance of cell fate. Depletion of miRNAs from embryonic stem cells impairs their differentiation capacity. Total elimination of miRNAs leads to premature senescence in normal cells and tissues through activation of the DNA-damage checkpoint, whereas ablation of miRNAs in cancer cell lines results in an ...